- npr-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to be located in plasma membrane. Expressed in ventral cord neurons. Human ortholog(s) of this gene implicated in hypertension. Is an ortholog of human PRLHR (prolactin releasing hormone receptor).
- Htr1e [Search on AGR]
Homo sapiens Enables Gi/o-coupled serotonin receptor activity; serotonin binding activity; and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
- Htr1f [Search on AGR]
Homo sapiens Enables Gi/o-coupled serotonin receptor activity; serotonin binding activity; and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
- dop-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including cellular response to amphetamine; male mating behavior; and regulation of locomotion involved in locomotory behavior. Predicted to be located in dendrite and plasma membrane. Expressed in GLR; male-specific anatomical entity; and neurons. Used to study Parkinson's disease and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol dependence; drug dependence (multiple); and end stage renal disease. Is an ortholog of human DRD3 (dopamine receptor D3).
- Mycl [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a targeted null allele are viable, fertile and apparently healthy with no congenital defects or gross morphological/cellular alterations of the CNS, lung, kidney and GI tract. [provided by MGI curators]
- Htr1d [Search on AGR]
Homo sapiens Enables Gi/o-coupled serotonin receptor activity and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway and intestine smooth muscle contraction. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
- gar-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cholinergic synaptic transmission; and response to xenobiotic stimulus. Located in axon. Expressed in neurons.
- Irag1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele show lower blood pressure, a slightly reduced heart rate, and failure of cGMP-mediated relaxation of receptor-triggered smooth muscle contraction; 50% of mice die prematurely with an enlarged stomach, a dilated cecum, pyloric stenosis and impaired GI motility. [provided by MGI curators]
- Rgs21 [Search on AGR]
Homo sapiens Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]
- Mlnr [Search on AGR]
Homo sapiens Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]