nhr-23

Caenorhabditis elegans

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Located in chromatin and nucleus. Expressed in several structures, including gonad; hypodermis; oocyte; spermatocyte; and vulval precursor cell. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 15 and immunodeficiency 42. Is an ortholog of human RORA (RAR related orphan receptor A); RORB (RAR related orphan receptor B); and RORC (RAR related orphan receptor C).

nhr-288

Caenorhabditis elegans

Is affected by hpl-2 and prg-1 based on tiling array studies. Is affected by Sirolimus based on microarray studies. Is predicted to encode a protein with the following domains: Ligand-binding domain of nuclear hormone receptor; Nuclear hormone receptor, ligand-binding domain; Nuclear hormone receptor-like domain superfamily; and Caenorhabditis elegans Orphan Nuclear Receptors.

Phospho2

Rattus norvegicus

Predicted to enable phosphatase activity. Orthologous to human PHOSPHO2 (phosphatase, orphan 2); PARTICIPATES IN vitamin B6 metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; bisphenol A.

CG4476

Drosophila melanogaster

CG4476 encodes an orphan member of the SLC6 family of transporters that includes the plasma membrane serotonin and dopamine transporters. CG4476 mutants show a decreased behavioral response to light.

Rhno1-ps2

Rattus norvegicus

Predicted to be involved in DNA damage checkpoint signaling and recombinational repair. Predicted to be active in chromosome and nucleus. Orthologous to human RHNO1 (RAD9-HUS1-RAD1 interacting nuclear orphan 1).

prt

Drosophila melanogaster

portabella (prt) encodes an orphan vesicular transporter expressed in a discrete number of cells in larvae and adults, including Kenyon cells of the mushroom bodies. prt depletion produces male mating behavior defects and a modest learning deficit.

sra-11

Caenorhabditis elegans

Predicted to enable olfactory receptor activity. Involved in detection of chemical stimulus involved in sensory perception and olfactory learning. Predicted to be located in membrane. Expressed in VC neuron; interneuron; pharyngeal neurons; and ventral ganglion.

Gpr101

Homo sapiens

The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]

Gpr82

Homo sapiens

The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]

knrl

Drosophila melanogaster

knirps-like (knrl) encodes an orphan nuclear hormone receptor with a C4 zinc finger motif, without ligand-binding domain. It is a target gene of the Hedgehog, Wingless and Notch signaling pathways. It controls endoreduplication domains and epithelial morphogenesis in the fore- and hindgut.