TMUE_2000007980

Trichuris muris

Is predicted to encode a protein with the following domains: DEK C terminal domain and DEK, C-terminal.

Dek

Drosophila melanogaster

Dek (Dek) encodes a DNA binding protein involved in DNA repair and heterochromatin integrity.

PPA39425

Pristionchus pacificus

Is predicted to encode a protein with the following domains: DEK C terminal domain and DEK, C-terminal.

OVOC11863

Onchocerca volvulus

Is predicted to encode a protein with the following domains: DEK C terminal domain and DEK, C-terminal. Is an ortholog of B. malayi Bm8921.

OVOC8141

Onchocerca volvulus

Is predicted to encode a protein with the following domains: SWIB/MDM2 domain; DEK C terminal domain; SWIB/MDM2 domain superfamily; DEK, C-terminal; and SWIB domain. Is an ortholog of C. elegans K03B8.4 and T24G10.2.

PPA14346

Pristionchus pacificus

Is predicted to encode a protein with the following domains: SWIB/MDM2 domain; DEK C terminal domain; SWIB/MDM2 domain superfamily; DEK, C-terminal; and SWIB domain. Is an ortholog of C. elegans T24G10.2.

Bm5991

Brugia malayi

Is predicted to encode a protein with the following domains: DEK, C-terminal; SWIB/MDM2 domain; SWIB/MDM2 domain superfamily; SWIB domain; and DEK C terminal domain. Is an ortholog of C. elegans K03B8.4 and T24G10.2.

npp-14

Caenorhabditis elegans

Enables caspase binding activity. Involved in negative regulation of execution phase of apoptosis. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Is an ortholog of human NUP214 (nucleoporin 214).

Dek

Rattus norvegicus

Predicted to enable histone binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase III and regulation of double-strand break repair. Predicted to act upstream of or within regulation of double-strand break repair via nonhomologous end joining. Predicted to be located in contractile muscle fiber and nucleoplasm. Predicted to be part of B-WICH complex. Predicted to be active in nucleus. Orthologous to human DEK (DEK proto-oncogene); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Nup214

Homo sapiens

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]