apg-1

Caenorhabditis elegans

Predicted to enable clathrin adaptor activity and clathrin binding activity. Involved in apical protein localization and protein secretion. Predicted to be located in Golgi apparatus and cytoplasmic vesicle membrane. Predicted to be part of AP-1 adaptor complex. Is an ortholog of human AP1G1 (adaptor related protein complex 1 subunit gamma 1).

apd-3

Caenorhabditis elegans

Predicted to be involved in intracellular transport and synaptic vesicle membrane organization. Predicted to be located in endosome membrane; presynaptic endosome; and terminal bouton. Predicted to be part of AP-3 adaptor complex. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome. Is an ortholog of human AP3D1 (adaptor related protein complex 3 subunit delta 1).

Y45G5AM.9

Caenorhabditis elegans

Predicted to enable clathrin binding activity. Predicted to be involved in intracellular transport. Predicted to be located in trans-Golgi network membrane. Predicted to be part of AP-1 adaptor complex. Is an ortholog of human AFTPH (aftiphilin).

aps-1

Caenorhabditis elegans

Involved in apical protein localization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of AP-1 adaptor complex. Human ortholog(s) of this gene implicated in MEDNIK syndrome; psoriasis 15; and syndromic X-linked intellectual disability 5. Is an ortholog of human AP1S1 (adaptor related protein complex 1 subunit sigma 1) and AP1S2 (adaptor related protein complex 1 subunit sigma 2).

APS1

Saccharomyces cerevisiae

Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex

ndx-4

Caenorhabditis elegans

Enables 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity and bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Involved in nucleotide metabolic process. Is an ortholog of human NUDT2 (nudix hydrolase 2).

unc-101

Caenorhabditis elegans

Predicted to enable clathrin adaptor activity. Involved in several processes, including cilium assembly; nematode larval development; and protein localization. Predicted to be located in clathrin-coated vesicle. Predicted to be part of AP-1 adaptor complex. Expressed in several structures, including germ line; head; and tail. Is an ortholog of human AP1M1 (adaptor related protein complex 1 subunit mu 1).

APS2

Saccharomyces cerevisiae

Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex

aptf-1

Caenorhabditis elegans

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and sleep. Predicted to be located in nucleus. Expressed in head neurons and pharyngeal neurons. Human ortholog(s) of this gene implicated in Char syndrome; branchiooculofacial syndrome; and dilated cardiomyopathy. Is an ortholog of human TFAP2C (transcription factor AP-2 gamma).

APM4

Saccharomyces cerevisiae

Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals