Psd2

Saccharomyces cerevisiae

Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected

mboa-3

Caenorhabditis elegans

Predicted to enable acyltransferase activity. Predicted to be involved in lipid modification. Predicted to be located in membrane. Is an ortholog of human MBOAT1 (membrane bound glycerophospholipid O-acyltransferase 1) and MBOAT2 (membrane bound glycerophospholipid O-acyltransferase 2).

mboa-4

Caenorhabditis elegans

Predicted to enable acyltransferase activity. Predicted to be involved in lipid modification. Predicted to be located in membrane. Is an ortholog of human MBOAT1 (membrane bound glycerophospholipid O-acyltransferase 1) and MBOAT2 (membrane bound glycerophospholipid O-acyltransferase 2).

ATG4

Saccharomyces cerevisiae

Conserved cysteine protease required for autophagy; functions in both early and late stages of autophagosome formation; primes Atg8p by removing the C-terminal arginine residue of nascent Atg8p in preparation for conjugation with phosphatidylethanolamide (PE), and also cleaves the PE modified, membrane-bound form to reverse conjugation; regulates the membrane-binding state of Atg8p, that is required for autophagosome formation and autophagy, as well as the cytoplasm-to-vacuole targeting pathway

PDR17

Saccharomyces cerevisiae

Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition

Pebp4

Homo sapiens

The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]

CAN1

Saccharomyces cerevisiae

Plasma membrane arginine permease; transceptor that senses extracellular basic amino acids; negative regulator of biofilm formation; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication

mboa-6

Caenorhabditis elegans

Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity and lysophospholipid acyltransferase activity. Involved in glycerophospholipid biosynthetic process; positive regulation of growth rate; and post-embryonic development. Predicted to be located in endoplasmic reticulum and membrane. Expressed in pharyngeal muscle cell and tail. Is an ortholog of human LPCAT3 (lysophosphatidylcholine acyltransferase 3).

tat-5

Caenorhabditis elegans

Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in embryo development. Located in cytoplasmic vesicle and plasma membrane. Expressed widely. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth and behavioral abnormalities. Is an ortholog of human ATP9B (ATPase phospholipid transporting 9B (putative)).

ATG8

Saccharomyces cerevisiae

Ubiquitin-like protein conjugated to phosphatidylethanolamine (PE); role in membrane fusion and phagophore expansion during autophagosome formation; deconjugation is also required for biogenesis; targets Atg1p to autophagosomes; binds to the Atg1p-Atg13p complex, triggers its vacuolar degradation; role in vacuolar membrane protein turnover during early stationary phase; component of autophagosomes and Cvt vesicles; targeted to vacuole via AP-3 pathway