PGRP-LF

Drosophila melanogaster

Peptidoglycan recognition protein LF (PGRP-LF) encodes a transmembrane receptor that prevents the spontaneous activation of the immune deficiency pathway receptor encoded by PGRP-LC.

Vps72

Saccharomyces cerevisiae

Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting

GAG1

Saccharomyces cerevisiae

Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus; Interacts with CKA2 in a potentially competitive mode with the CK2 holoenzyme. Structural prediction analysis reveals a clamp-domain (rear, hinge, front), an unstructured gag region, and a lock-domain

Xdh

Mus musculus

PHENOTYPE: Homozygotes for a null allele are small and die prematurely while heterozygous females show a lactation defect. Most homozygotes for another null allele die within the first month of renal failure associated with uric acid depletion, renal tubular damage, inflammation, fibrosis and oxidative stress. Homozygosity for mutations that lock the enzyme into the xanthine oxidase (XO) form leads to increased number of peritoneal macrophages and increased ROS production after their stimulation. This in turn stimulates xenografted tumor growth. [provided by MGI curators]

ifta-2

Caenorhabditis elegans

Predicted to enable GTPase activity. Involved in several processes, including dauer larval development; determination of adult lifespan; and insulin-like growth factor receptor signaling pathway. Located in axoneme and ciliary base. Expressed in amphid neurons and phasmid neurons. Is an ortholog of human IFT22 (intraflagellar transport 22).

L3mbtl1

Rattus norvegicus

Predicted to enable several functions, including SAM domain binding activity; identical protein binding activity; and methylated histone binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule biosynthetic process; regulation of megakaryocyte differentiation; and regulation of mitotic nuclear division. Predicted to be located in chromatin; condensed chromosome; and nucleoplasm. Predicted to be part of chromatin lock complex. Predicted to be active in nucleus. Orthologous to human L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; INTERACTS WITH atrazine; bisphenol A; lead diacetate.

Rb1

Rattus norvegicus

Predicted to enable several functions, including disordered domain specific binding activity; enzyme binding activity; and importin-alpha family protein binding activity. Involved in negative regulation of apoptotic process; negative regulation of cell cycle; and spermatogenesis. Predicted to be located in PML body; cytoplasm; and spindle. Predicted to be part of Rb-E2F complex; chromatin lock complex; and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in chromatin. Biomarker of acute kidney failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including high grade glioma (multiple); osteosarcoma; prostate cancer; retinoblastoma (multiple); and small cell carcinoma. Orthologous to human RB1 (RB transcriptional corepressor 1); PARTICIPATES IN ceramide signaling pathway; G1/S transition pathway; RNA polymerase III transcription pathway; INTERACTS WITH (Z)-3-butylidenephthalide; 17alpha-ethynylestradiol; 17beta-estradiol.

rsp-6

Caenorhabditis elegans

Predicted to enable mRNA binding activity. Involved in gonad development and regulation of termination of DNA-templated transcription. Located in nucleus. Expressed in several structures, including PVDL and PVDR. Human ortholog(s) of this gene implicated in bipolar disorder; clear cell renal cell carcinoma; and ovary epithelial cancer. Is an ortholog of human SRSF7 (serine and arginine rich splicing factor 7).

pam-1

Caenorhabditis elegans

Enables metalloaminopeptidase activity. Involved in several processes, including exit from meiosis; first cell cycle pseudocleavage; and regulation of reproductive process. Located in condensed chromosome; cytoplasm; and mitotic spindle pole. Expressed in amphid process; intestine; male-specific anatomical entity; nerve ring; and tail neurons. Is an ortholog of human NPEPPS (aminopeptidase puromycin sensitive).

Antxr1

Homo sapiens

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]