dpy-19

Caenorhabditis elegans

Enables mannosyltransferase activity. Involved in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan. Located in perinuclear region of cytoplasm. Expressed in several structures, including P1; P2; QL; QR; and seam cell. Human ortholog(s) of this gene implicated in spermatogenic failure 9. Is an ortholog of human DPY19L2 (dpy-19 like 2).

his-72

Caenorhabditis elegans

Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Located in nucleus. Part of nucleosome. Expressed in several structures, including germ cell; somatic cell; and in male. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 1 and Bryant-Li-Bhoj neurodevelopmental syndrome 2. Is an ortholog of human H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B).

his-71

Caenorhabditis elegans

Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be located in nucleus. Predicted to be part of nucleosome. Expressed in several structures, including somatic cell. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 1 and Bryant-Li-Bhoj neurodevelopmental syndrome 2. Is an ortholog of human H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B).

CCN2-AS1

Homo sapiens

ASSOCIATED WITH Generalized Arterial Calcification of Infancy, 1; Kyphomelic Dysplasia; spondyloepimetaphyseal dysplasia, Li-Shao-Li type

chk-2

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Expressed in germline blastomere. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); and germ cell cancer (multiple). Is an ortholog of human CHEK2 (checkpoint kinase 2).

hch-1

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Involved in hatching and neuron migration. Predicted to be located in extracellular region. Expressed in hypodermis and seam cell.

chkr-2

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); and germ cell cancer (multiple). Is an ortholog of human CHEK2 (checkpoint kinase 2).

mig-21

Caenorhabditis elegans

Predicted to enable signaling receptor activity. Involved in several processes, including cell migration; determination of left/right asymmetry in nervous system; and regulation of canonical Wnt signaling pathway. Predicted to be located in plasma membrane. Expressed in QL; QR; and body wall musculature.

ENA1

Saccharomyces cerevisiae

P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance

pig-1

Caenorhabditis elegans

Enables protein serine/threonine kinase activity. Involved in several processes, including generation of neurons; hemidesmosome assembly; and regulation of apoptotic process. Located in centrosome and cytoplasm. Expressed in several structures, including AVM; Q lineage cell; QL.aa; QL.pp; and nerve ring neurons. Is an ortholog of human MELK (maternal embryonic leucine zipper kinase).