Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Located in nucleus. Part of nucleosome. Expressed in several structures, including germ cell; somatic cell; and in male. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 1 and Bryant-Li-Bhoj neurodevelopmental syndrome 2. Is an ortholog of human H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B).
Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be located in nucleus. Predicted to be part of nucleosome. Expressed in several structures, including somatic cell. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 1 and Bryant-Li-Bhoj neurodevelopmental syndrome 2. Is an ortholog of human H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B).
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Expressed in germline blastomere. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); and germ cell cancer (multiple). Is an ortholog of human CHEK2 (checkpoint kinase 2).
Predicted to enable several functions, including ATP binding activity; helicase activity; and nucleic acid binding activity. Predicted to be located in cytoplasm. Is an ortholog of human DDX60 (DExD/H-box helicase 60) and DDX60L (DExD/H-box 60 like).
Predicted to enable box H/ACA snoRNA binding activity. Predicted to be involved in snoRNA guided rRNA pseudouridine synthesis. Predicted to be located in nucleolus. Predicted to be part of box H/ACA snoRNP complex. Is an ortholog of human GAR1 (GAR1 ribonucleoprotein).
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); and germ cell cancer (multiple). Is an ortholog of human CHEK2 (checkpoint kinase 2).
Is affected by clk-1; etr-1; and fmi-1 based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Nematode receptor-like serpentine class H; Serpentine type 7TM GPCR chemoreceptor Srh; and 7TM GPCR, serpentine receptor class h (Srh).
PHENOTYPE: Electrophoretic variants are known for this locus. The a allele determines a fast migrating band in BALB/c, CBA/H, C3H/He and C57BL/6; the b allele, a slow band in NZC; the c allele, the fastest band in DBA/Li, NFS/N, STS, 101/H and 129. [provided by MGI curators]