his-72

Caenorhabditis elegans

Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Located in nucleus. Part of nucleosome. Expressed in several structures, including germ cell; somatic cell; and in male. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 1 and Bryant-Li-Bhoj neurodevelopmental syndrome 2. Is an ortholog of human H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B).

his-71

Caenorhabditis elegans

Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be located in nucleus. Predicted to be part of nucleosome. Expressed in several structures, including somatic cell. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 1 and Bryant-Li-Bhoj neurodevelopmental syndrome 2. Is an ortholog of human H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B).

CCN2-AS1

Homo sapiens

ASSOCIATED WITH Generalized Arterial Calcification of Infancy, 1; Kyphomelic Dysplasia; spondyloepimetaphyseal dysplasia, Li-Shao-Li type

chk-2

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Expressed in germline blastomere. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); and germ cell cancer (multiple). Is an ortholog of human CHEK2 (checkpoint kinase 2).

chkr-2

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); and germ cell cancer (multiple). Is an ortholog of human CHEK2 (checkpoint kinase 2).

ENA1

Saccharomyces cerevisiae

P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance

ENA2

Saccharomyces cerevisiae

P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux

F43B10.1

Caenorhabditis elegans

Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of human PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha) and PPP2R3B (protein phosphatase 2 regulatory subunit B''beta).

sto-3

Caenorhabditis elegans

Predicted to be located in plasma membrane. Expressed in RIB; ray neuron type B; and tail.

ldh-1

Caenorhabditis elegans

Enables L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process and pyruvate metabolic process. Predicted to be located in mitochondrion. Expressed in tail. Is an ortholog of several human genes including LDHA (lactate dehydrogenase A); LDHB (lactate dehydrogenase B); and LDHC (lactate dehydrogenase C).