ril-2

Caenorhabditis elegans

Predicted to be involved in lysosome organization and regulation of intracellular pH. Predicted to be located in lysosome.

Y37D8A.25

Caenorhabditis elegans

Enriched in AFD; MSpaaapa; germ line; intestine; and oocyte based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including etr-1; hpl-2; and pptr-1 based on tiling array; RNA-seq; and microarray studies. Is affected by four chemicals including hydrogen sulfide; Zidovudine; and rifampin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: PH domain; PH-like domain superfamily; and Pleckstrin homology domain. Is an ortholog of human PHETA1 (PH domain containing endocytic trafficking adaptor 1); PHETA2 (PH domain containing endocytic trafficking adaptor 2); and PLEKHJ1 (pleckstrin homology domain containing J1). Human PHETA1 enables protein homodimerization activity.

tag-77

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cytoskeleton organization and filopodium assembly. Predicted to be located in cytoplasm. Expressed in hermaphrodite gonad and somatic gonad precursor. Is an ortholog of human FGD5 (FYVE, RhoGEF and PH domain containing 5) and FGD6 (FYVE, RhoGEF and PH domain containing 6).

K10B4.3

Caenorhabditis elegans

Predicted to enable phosphatidylinositol-5-phosphate binding activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in plasma membrane. Is an ortholog of human VEPH1 (ventricular zone expressed PH domain containing 1).

frm-5.2

Caenorhabditis elegans

Enriched in OLL; PVD; head mesodermal cell; oocyte; and sensory neurons based on microarray and RNA-seq studies. Is affected by several genes including cyc-1; etr-1; and osm-3 based on microarray; tiling array; RNA-seq; and proteomic studies. Is affected by eleven chemicals including metformin; Sirolimus; and silicon dioxide nanoparticle based on RNA-seq; microarray; and proteomic studies. Is predicted to encode a protein with the following domains: PH-like domain superfamily; FERM, N-terminal; PDZ domain; FERM central domain; FERM/acyl-CoA-binding protein superfamily; Ubiquitin-like domain superfamily; Non-receptor Tyrosine-protein Phosphatases; Band 4.1 domain; FERM C-terminal PH-like domain; FERM N-terminal domain; FERM, C-terminal PH-like domain; PDZ superfamily; and FERM superfamily, second domain. Is an ortholog of human FRMPD2 (FERM and PDZ domain containing 2). Human FRMPD2 enables 1-phosphatidylinositol binding activity.

gphr-1

Caenorhabditis elegans

Predicted to enable voltage-gated monoatomic anion channel activity. Predicted to be involved in intracellular pH reduction. Predicted to be located in Golgi cisterna membrane. Is an ortholog of human GPR89A (G protein-coupled receptor 89A) and GPR89B (G protein-coupled receptor 89B).

gphr-2

Caenorhabditis elegans

Predicted to enable voltage-gated monoatomic anion channel activity. Predicted to be involved in intracellular pH reduction. Predicted to be located in Golgi cisterna membrane. Is an ortholog of human GPR89A (G protein-coupled receptor 89A) and GPR89B (G protein-coupled receptor 89B).

F31D4.5

Caenorhabditis elegans

Enriched in several structures, including accessory cell; intestine; neurons; oocyte; and tail hypodermis based on RNA-seq; tiling array; and single-cell RNA-seq studies. Is affected by several genes including mxl-2; nuo-6; and atfs-1 based on microarray and RNA-seq studies. Is affected by nineteen chemicals including 1-methylnicotinamide; methylmercuric chloride; and rotenone based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: PH domain; PH-like domain superfamily; and Pleckstrin homology domain. Is an ortholog of human PLEKHD1 (pleckstrin homology and coiled-coil domain containing D1).

gcy-9

Caenorhabditis elegans

Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in several processes, including cellular response to acidic pH; detection of chemical stimulus; and positive regulation of neuronal action potential. Located in neuronal cell body and non-motile cilium. Expressed in BAGL and BAGR.

acd-1

Caenorhabditis elegans

Predicted to enable ligand-gated sodium channel activity. Involved in response to acidic pH and sodium ion transport. Predicted to be located in plasma membrane. Expressed in AMshL and AMshR. Is an ortholog of human ASIC4 (acid sensing ion channel subunit family member 4).