M05D6.2

Caenorhabditis elegans

Predicted to be involved in signal transduction. Is an ortholog of human TCP11 (t-complex 11); TCP11L1 (t-complex 11 like 1); and TCP11L2 (t-complex 11 like 2).

hmg-1.2

Caenorhabditis elegans

Enables transcription cis-regulatory region binding activity. Involved in several processes, including Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Expressed in several structures, including tail. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; alcohol dependence; and alcohol use disorder. Is an ortholog of human HMGB3 (high mobility group box 3).

mam-1

Caenorhabditis elegans

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in regulation of T cell activation and regulation of T cell migration. Predicted to be located in membrane.

C35B8.3

Caenorhabditis elegans

Predicted to be located in mitochondrion. Is an ortholog of human TCAIM (T cell activation inhibitor, mitochondrial).

Btnl2

Rattus norvegicus

Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to act upstream of or within negative regulation of T cell receptor signaling pathway; positive regulation of T cell proliferation; and positive regulation of interleukin-2 production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); berylliosis; coronary artery disease; and sarcoidosis. Orthologous to human BTNL2 (butyrophilin like 2); INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; endosulfan.

tbx-40

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and nucleus. Expressed in phasmid neurons. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and bone disease (multiple). Is an ortholog of several human genes including TBX15 (T-box transcription factor 15); TBX4 (T-box transcription factor 4); and TBX6 (T-box transcription factor 6).

C38H2.2

Caenorhabditis elegans

Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in membrane. Expressed in several structures, including tail. Is an ortholog of human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1).

tbx-9

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic body morphogenesis. Located in nucleus. Expressed in several structures, including ABarpa; Eal; Ear; Epl; and Epr. Human ortholog(s) of this gene implicated in several diseases, including Holt-Oram syndrome; asthma, nasal polyps, and aspirin intolerance; and malaria. Is an ortholog of several human genes including EOMES (eomesodermin); TBR1 (T-box brain transcription factor 1); and TBX5 (T-box transcription factor 5).

cct-1

Caenorhabditis elegans

Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in nucleus. Part of chaperonin-containing T-complex. Expressed in nerve ring and in male. Is an ortholog of human TCP1 (t-complex 1).

I-t

Drosophila melanogaster

inhibitor-t (I-t) encodes a protein phosphatase inhibitor.