Fili

Drosophila melanogaster

Fish-lips (Fili) encodes a leucine-rich repeat family transmembrane protein. It regulates autonomous and nonautonomous apoptosis caused by the dioxin receptor homolog encoded by ss.

LHP1

Saccharomyces cerevisiae

RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen

chhy-1

Caenorhabditis elegans

Enables hexosaminidase activity. Involved in chondroitin sulfate catabolic process. Expressed in PLML; PLMR; head; intestinal cell; and vulva. Human ortholog(s) of this gene implicated in mucopolysaccharidosis IX. Is an ortholog of human HYAL2 (hyaluronidase 2).

ss

Drosophila melanogaster

spineless (ss) encodes a protein that plays a key role in defining the distal regions of the antenna and the leg. Its stochastic expression in R7 photoreceptors also controls the expression of color Rhodopsins (the product of Rh4 vs. the product of Rh3) in the two subsets of ommatidia.

Slco1a1

Rattus norvegicus

Enables organic anion transmembrane transporter activity. Involved in organic anion transport and response to testosterone. Located in membrane. Biomarker of Dubin-Johnson syndrome and primary biliary cholangitis. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 11-deoxycorticosterone.

RT1-M10-ps4

Rattus norvegicus

Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-F (major histocompatibility complex, class I, F).

Ssna1

Rattus norvegicus

Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be involved in axonogenesis; cell division; and microtubule nucleation. Predicted to act upstream of or within intraciliary transport and receptor clustering. Predicted to be located in cytoskeleton; midbody; and supramolecular fiber. Predicted to be active in axon; centrosome; and ciliary basal body. Orthologous to human SSNA1 (SS nuclear autoantigen 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 4,4'-sulfonyldiphenol.

Slco1a4

Rattus norvegicus

Enables bile acid transmembrane transporter activity. Involved in cellular response to xenobiotic stimulus; response to estrogen; and sodium-independent organic anion transport. Located in basal plasma membrane. Biomarker of Dubin-Johnson syndrome; cholestasis; and steatotic liver disease. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2); PARTICIPATES IN multispecific organic anion transporter mediated transport pathway; bile acid transport pathway; INTERACTS WITH (+)-pilocarpine; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene; 1-benzylpiperazine.

Rnase1

Homo sapiens

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

old-1

Caenorhabditis elegans

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Expressed in hypodermis; male gonad; neurons; and pharynx. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and prostate cancer. Is an ortholog of human FLT3 (fms related receptor tyrosine kinase 3).