Slco1a1

Rattus norvegicus

Enables organic anion transmembrane transporter activity. Involved in organic anion transport and response to testosterone. Located in membrane. Biomarker of Dubin-Johnson syndrome and primary biliary cholangitis. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 11-deoxycorticosterone.

RT1-M10-ps4

Rattus norvegicus

Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-F (major histocompatibility complex, class I, F).

Slco1a4

Rattus norvegicus

Enables bile acid transmembrane transporter activity. Involved in cellular response to xenobiotic stimulus; response to estrogen; and sodium-independent organic anion transport. Located in basal plasma membrane. Biomarker of Dubin-Johnson syndrome; cholestasis; and steatotic liver disease. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2); PARTICIPATES IN multispecific organic anion transporter mediated transport pathway; bile acid transport pathway; INTERACTS WITH (+)-pilocarpine; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene; 1-benzylpiperazine.

old-1

Caenorhabditis elegans

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Expressed in hypodermis; male gonad; neurons; and pharynx. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and prostate cancer. Is an ortholog of human FLT3 (fms related receptor tyrosine kinase 3).

RT1-CE2

Rattus norvegicus

Predicted to be involved in antigen processing and presentation of peptide antigen via MHC class I. Predicted to be located in lumenal side of endoplasmic reticulum membrane and phagocytic vesicle membrane. Predicted to be part of MHC class I protein complex. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-F (major histocompatibility complex, class I, F); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 17alpha-ethynylestradiol; acetamide; ammonium chloride.

Abcc2

Rattus norvegicus

Enables ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Involved in several processes, including carboxylic acid transport; cellular response to cytokine stimulus; and cellular response to dexamethasone stimulus. Located in brush border membrane and intracellular canaliculus. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal disease; and epilepsy. Biomarker of bilirubin metabolic disorder; cholestasis; liver disease (multiple); status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (S)-colchicine.

Abcc2

Homo sapiens

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

RT1-A1

Rattus norvegicus

Enables beta-2-microglobulin binding activity and peptide binding activity. Involved in T cell tolerance induction; negative regulation of natural killer cell mediated cytotoxicity; and positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. Used to study graft-versus-host disease. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-F (major histocompatibility complex, class I, F); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium acetate.

H2-m10.6l

Rattus norvegicus

Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-F (major histocompatibility complex, class I, F).

RT1-M2

Rattus norvegicus

Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-F (major histocompatibility complex, class I, F); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acetamide.