Lrrc31 [Search on AGR]
Homo sapiens ASSOCIATED WITH autosomal dominant dyskeratosis congenita 1; Fanconi-Bickel syndrome; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1
Slc2a2 [Search on AGR]
Homo sapiens This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Slc2a2 [Search on AGR]
Rattus norvegicus Enables D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and insulin receptor binding activity. Involved in several processes, including carbohydrate utilization; dehydroascorbic acid transport; and hexose transmembrane transport. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Human ortholog(s) of this gene implicated in Fanconi-Bickel syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2); PARTICIPATES IN facilitative sugar transporter mediated glucose transport pathway; Fanconi syndrome pathway; forkhead class A signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.