PGRP-SD

Drosophila melanogaster

Peptidoglycan recognition protein SD (PGRP-SD) encodes a secreted member of the peptidoglycan recognition protein of from Gram negative bacteria. It is a positive regulator of the Imd pathway by promoting the recognition of peptidoglycan.

CBN32192

Caenorhabditis brenneri

Is predicted to encode a protein with the following domains: Homeobox protein SIX1, N-terminal SD domain and Transcriptional regulator, SIX1, N-terminal SD domain. Is an ortholog of C. elegans ceh-34. In C. elegans, ceh-34 is involved in mesodermal cell fate specification; positive regulation of apoptotic process involved in development; and regulation of DNA-templated transcription.

TMUE_1000004182

Trichuris muris

Is predicted to encode a protein with the following domains: Homeobox protein SIX1, N-terminal SD domain and Transcriptional regulator, SIX1, N-terminal SD domain. Is an ortholog of C. elegans ceh-34 and unc-39. In C. elegans, ceh-34 is involved in mesodermal cell fate specification; positive regulation of apoptotic process involved in development; and regulation of DNA-templated transcription.

Tgi

Drosophila melanogaster

Tondu-domain-containing Growth Inhibitor (Tgi) encodes a protein that interacts with both components of the sd-yki transcriptional complex to inhibit its activity and thus restrict tissue growth.

vg

Drosophila melanogaster

vestigial (vg) encodes a wing/haltere identity selector gene. It functions as a transcriptional activator when bound to the product of sd to direct wing specific gene expression and regulate cell proliferation. It also has a role in muscle specification.

sd

Drosophila melanogaster

scalloped (sd) encodes a DNA binding protein of the TEAD class. It requires co-factor proteins ,such as the products of vg and yki, to act as a transcription factor, and is modified by Hippo and Wingless signalling. It is involved in wing and neuronal specification.

SKI2

Saccharomyces cerevisiae

Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome

yki

Drosophila melanogaster

yorkie (yki) encodes a transcriptional co-activator protein that is negatively regulated by Hippo signaling, which promotes its cytoplasmic localization. It functions together with DNA binding proteins, such as the product of sd, to activate transcription of a wide range of downstream targets, including genes that promote growth.

SKI3

Saccharomyces cerevisiae

Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; role in preventing L-A mycovirus pathogenesis; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome

B4galnt2

Homo sapiens

B4GALNT2 catalyzes the last step in the biosynthesis of the human Sd(a) antigen through the addition of an N-acetylgalactosamine residue via a beta-1,4 linkage to a subterminal galactose residue substituted with an alpha-2,3-linked sialic acid. B4GALNT2 also catalyzes the last step in the biosynthesis of the Cad antigen (Montiel et al., 2003 [PubMed 12678917]).[supplied by OMIM, Mar 2008]