cpz-2

Caenorhabditis elegans

Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in extracellular space and lysosome. Is an ortholog of human CTSZ (cathepsin Z).

cap-1

Caenorhabditis elegans

Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and barbed-end actin filament capping. Part of dynactin complex. Expressed in rectal valve cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in male infertility. Is an ortholog of human CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1) and CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2).

ZK1321.4

Caenorhabditis elegans

Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Predicted to be involved in actin cytoskeleton organization and muscle structure development. Predicted to be located in Z disc; adherens junction; and stress fiber. Predicted to be part of filamentous actin.

rba-1

Caenorhabditis elegans

Predicted to enable histone binding activity. Involved in cell fate specification; nematode male tail tip morphogenesis; and regulation of neurogenesis. Predicted to be located in nucleus. Predicted to be part of ESC/E(Z) complex and NuRD complex. Is an ortholog of human RBBP7 (RB binding protein 7, chromatin remodeling factor).

Ly31

Mus musculus

PHENOTYPE: This locus controls an antigen on T- and B-lymphocytes. The a allele determines presence of Ly31.1 in A/He, AKR, BALB/c, C3H/He, DBA/2, SWR; the b allele determines absence in C57BL, DBA/1, SM, 129. Ly31.1 antigen was shown to be an alkaline phosphatase. [provided by MGI curators]

Ly34

Mus musculus

PHENOTYPE: This locus controls an antigen on T-cells and in brain, liver and kidney. The b allele determines antigen presence in C58, C3H/He, DBA/2, NZB, P, CE and C57 strains; the a allele determines absence in C57BLKS, A/He, AKR, CBA/J, DBA/1, BALB/c, HRS and STS. [provided by MGI curators]

Sas2

Mus musculus

PHENOTYPE: Sas2 controls an antigen seen in reciprocal immunization of BALB/c and MOL/ANJ. The a allele determines antigen specificity in most inbreds, e.g., A/He, AKR, BALB/c, C3H/He, C57BL/6, DBA/2, NZB; the b allele determines specificity in M.m. molossinus derived strains. Heterozygotes have both antigens. [provided by MGI curators]

cpz-1

Caenorhabditis elegans

Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including ecdysis, collagen and cuticulin-based cuticle; gonad morphogenesis; and post-embryonic development. Located in collagen and cuticulin-based cuticle extracellular matrix; extracellular space; and yolk granule. Expressed in several structures, including anterior hypodermis; cuticle; intestine; pharynx; and vulva. Is an ortholog of human CTSZ (cathepsin Z).

Su(z)12

Drosophila melanogaster

Su(z)12 (Su(z)12) is a member of the Polycomb group of genes with products involved in transcriptional silencing. Su(z)12 encodes a subunit of Polycomb repressive complex 2 (PRC2), where it is required for the histone methyltransferase activity that yields trimethylation of histone H3 on lysine 27 (H3-K27me3).

Epa1

Mus musculus

PHENOTYPE: This locus controls presence or absence of an epidermal antigen inducing CTL in H2 compatible hosts lacking the antigen. Antigen is present in AKR, BALB/c, CBA/J, C3H/Bi, C57BL and DBA; and absent in C3H/He, C3H/An, A/J, A/He, LG and ST/b. This locus also acts like a minor histocompatibility locus. [provided by MGI curators]