- tdo-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in tryptophan catabolic process to acetyl-CoA. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Is an ortholog of human TDO2 (tryptophan 2,3-dioxygenase).
- Slitrk1 [Search on AGR]
Rattus norvegicus Involved in regulation of synapse organization. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and trichotillomania. Orthologous to human SLITRK1 (SLIT and NTRK like family member 1); INTERACTS WITH 17alpha-ethynylestradiol; alpha-Zearalanol; bisphenol A.
- HHT1 [Search on AGR]
Saccharomyces cerevisiae Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage
- HHT2 [Search on AGR]
Saccharomyces cerevisiae Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage
- Tdo2 [Search on AGR]
Rattus norvegicus Enables several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Involved in several processes, including L-tryptophan catabolic process to acetyl-CoA; response to cortisol; and response to nitroglycerin. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase); PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol.
- Hdc [Search on AGR]
Rattus norvegicus Enables several functions, including histidine decarboxylase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Involved in L-histidine metabolic process and histamine metabolic process. Located in dendrite and neuronal cell body. Biomarker of rhinitis. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,5'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
- Hcn4 [Search on AGR]
Rattus norvegicus Predicted to enable identical protein binding activity and monoatomic cation channel activity. Involved in cellular response to aldosterone. Located in basolateral plasma membrane; neuronal cell body; and terminal bouton. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.
- Drd4 [Search on AGR]
Rattus norvegicus Enables dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and heterocyclic compound binding activity. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and regulation of signal transduction. Located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and perikaryon. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Biomarker of attention deficit hyperactivity disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human DRD4 (dopamine receptor D4); PARTICIPATES IN dopamine signaling pathway; excitatory synaptic transmission pathway; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH (+)-butaclamol; 1,2-dimethylhydrazine; 3,7-dihydropurine-6-thione.
- Baiap2 [Search on AGR]
Rattus norvegicus Enables PDZ domain binding activity; scaffold protein binding activity; and transcription coregulator binding activity. Involved in several processes, including cellular response to L-glutamate; cellular response to epidermal growth factor stimulus; and regulation of synapse organization. Located in several cellular components, including dendrite; lamellipodium; and neuron projection branch point. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density, intracellular component; and presynaptic cytosol. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene.
- Cntnap2 [Search on AGR]
Homo sapiens This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2, a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and intellectual disability. [provided by RefSeq, Jul 2017]