mec-2

Caenorhabditis elegans

Enables cholesterol binding activity. Involved in positive regulation of multicellular organismal process and response to mechanical stimulus. Located in neuron projection membrane. Expressed in sensory neurons. Used to study nephrotic syndrome. Is an ortholog of human STOM (stomatin).

igdb-1

Caenorhabditis elegans

Predicted to be involved in sarcomere organization. Predicted to be located in M band.

F29A7.6

Caenorhabditis elegans

Predicted to be involved in maturation of 5.8S rRNA. Expressed widely. Is an ortholog of human MPHOSPH6 (M-phase phosphoprotein 6).

igdb-2

Caenorhabditis elegans

Predicted to be involved in sarcomere organization. Predicted to be located in M band. Expressed in amphid sheath cell; amphid socket cell; and hypodermis.

bus-6

Caenorhabditis elegans

Expressed in intestine.

mls-2

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment of mitotic spindle orientation; neuron differentiation involved in amphid sensory organ development; and regulation of cell differentiation. Located in nucleus. Expressed in several structures, including AB lineage cell; AWC-ON; M.dla; head; and somatic nervous system. Human ortholog(s) of this gene implicated in oculoauricular syndrome. Is an ortholog of human HMX1 (H6 family homeobox 1).

gtl-1

Caenorhabditis elegans

Predicted to enable monoatomic cation channel activity. Involved in defecation. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; and congenital stationary night blindness 1C. Is an ortholog of human TRPM1 (transient receptor potential cation channel subfamily M member 1); TRPM3 (transient receptor potential cation channel subfamily M member 3); and TRPM7 (transient receptor potential cation channel subfamily M member 7).

cpna-1

Caenorhabditis elegans

Enables phosphatase binding activity and protein-macromolecule adaptor activity. Involved in positive regulation of sarcomere organization. Located in M band and striated muscle dense body. Expressed in body wall musculature.

mec-10

Caenorhabditis elegans

Enables ligand-gated sodium channel activity. Involved in positive regulation of multicellular organismal process and response to mechanical stimulus. Located in cell body membrane. Expressed in neurons. Human ortholog(s) of this gene implicated in bronchiectasis (multiple); neuroblastoma; and renal tubular transport disease (multiple). Is an ortholog of human SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma).

cdc-25.4

Caenorhabditis elegans

Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of G2/MI transition of meiotic cell cycle. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including ganglia; germ line; male-specific anatomical entity; pharyngeal cell; and ventral nerve cord.