- dpyd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and gallbladder cancer. Is an ortholog of human DPYD (dihydropyrimidine dehydrogenase).
- cpz-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in extracellular space and lysosome. Is an ortholog of human CTSZ (cathepsin Z).
- M7324Wlst [Search on AGR]
Mus musculus PHENOTYPE: Mice heterozygous for an ENU-induced allele exhibit delayed recovery from 5-FU treatment. [provided by MGI curators]
- M7325Wlst [Search on AGR]
Mus musculus PHENOTYPE: Mice heterozygous for an ENU-induced allele exhibit excessive production of platelets following 5-FU treatment. [provided by MGI curators]
- M7321Wlst [Search on AGR]
Mus musculus PHENOTYPE: Mice heterozygous for an ENU-induced allele exhibit excessive platelet production following 5-FU treatment. [provided by MGI curators]
- upp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables thymidine phosphorylase activity and uridine phosphorylase activity. Involved in thymidine metabolic process; uracil catabolic process; and uridine catabolic process. Predicted to be located in cytosol. Expressed in gonad; hypodermis; pharynx; and spermatheca. Is an ortholog of human UPP1 (uridine phosphorylase 1) and UPP2 (uridine phosphorylase 2).
- cap-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and barbed-end actin filament capping. Part of dynactin complex. Expressed in rectal valve cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in male infertility. Is an ortholog of human CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1) and CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2).
- ZK1321.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Predicted to be involved in actin cytoskeleton organization and muscle structure development. Predicted to be located in Z disc; adherens junction; and stress fiber. Predicted to be part of filamentous actin.
- LOG1 [Search on AGR]
Saccharomyces cerevisiae Putative protein of unknown function; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA
- HAM1 [Search on AGR]
Saccharomyces cerevisiae Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA