- Tnnc2 [Search on AGR]
Homo sapiens Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
- C16D9.6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Tn polyagglutination syndrome and hemolytic-uremic syndrome. Is an ortholog of human C1GALT1C1 (C1GALT1 specific chaperone 1).
- tn [Search on AGR]
Drosophila melanogaster thin (tn) encodes a TRIM/RBCC protein involved in myofibril assembly and stability.
- SIGLEC6 [Search on AGR]
Homo sapiens This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]
- Pgant2 [Search on AGR]
Drosophila melanogaster Polypeptide N-Acetylgalactosaminyltransferase 2 (Pgant2) encodes a Golgi transmembrane protein that catalyzes the attachment of N-acetyl-alpha-D-galactosamine (GalNAc) to the hydroxyl group of serine or threonine residues in selected membrane or secreted proteins. This O-linked GalNAc glycan is known as the Tn antigen and can be further elongated with additional sugars.
- Pgant8 [Search on AGR]
Drosophila melanogaster Polypeptide N-Acetylgalactosaminyltransferase 8 (Pgant8) encodes a Golgi transmembrane protein that catalyzes the attachment of N-acetyl-alpha-D-galactosamine (GalNAc) to the hydroxyl group of serine or threonine residues in selected membrane or secreted proteins. This O-linked GalNAc glycan is known as the Tn antigen and can be further elongated with additional sugars.
- Pgant1 [Search on AGR]
Drosophila melanogaster Polypeptide N-Acetylgalactosaminyltransferase 1 (Pgant1) encodes a Golgi transmembrane protein that catalyzes the attachment of N-acetyl-alpha-D-galactosamine (GalNAc) to the hydroxyl group of serine or threonine residues in selected membrane or secreted proteins. This O-linked GalNAc glycan is known as the Tn antigen and can be further elongated with additional sugars.
- Pgant6 [Search on AGR]
Drosophila melanogaster Polypeptide N-Acetylgalactosaminyltransferase 6 (Pgant6) encodes a Golgi transmembrane protein that catalyzes the attachment of N-acetyl-alpha-D-galactosamine (GalNAc) to the hydroxyl group of serine or threonine residues in selected membrane or secreted proteins that have already an O-linked GalNAc modification. This O-linked GalNAc glycan is known as the Tn antigen and can be further elongated with additional sugars.
- Pgant7 [Search on AGR]
Drosophila melanogaster Polypeptide N-Acetylgalactosaminyltransferase 7 (Pgant7) encodes a Golgi transmembrane protein that catalyzes the attachment of N-acetyl-alpha-D-galactosamine (GalNAc) to the hydroxyl group of serine or threonine residues in selected membrane or secreted proteins that have already an O-linked GalNAc modification. This O-linked GalNAc glycan is known as the Tn antigen and can be further elongated with additional sugars.
- St6galnac1 [Search on AGR]
Homo sapiens Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]