- Alh [Search on AGR]
Drosophila melanogaster Alhambra (Alh) encodes a zinc finger/leucine zipper nuclear protein. It is required in the nervous system for maintaining eve expression and normal growth. It is also involved in muscle development and male courtship behavior.
- eve [Search on AGR]
Drosophila melanogaster even skipped (eve) encodes a homeobox-containing transcriptional repressor that acts in concert with co-repressors such as those enoded by gro and Gug. It represses pair-rule and segment polarity genes, contributing to anterior/posterior axis specification and mesoderm and central nervous system development.
- Evx1 [Search on AGR]
Homo sapiens This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. [provided by RefSeq, Jul 2008]
- Dbx [Search on AGR]
Drosophila melanogaster Dbx (Dbx) encodes a homedomain transcription factor expressed in distinct subsets of interneurons. It helps control the differentiation of these neurons, which tend to extend short axons and be GABA-ergic, via cross-repressive interactions with the products of exex and eve. The roles of the product of Dbx include neuronal specification and differentiation.
- exex [Search on AGR]
Drosophila melanogaster extra-extra (exex) encodes a homeodomain transcription factor that is expressed in and regulates the differentiation of motor neurons that project axons to ventral body wall muscles. Within the central nervous system, the product of exex negatively interacts with the products of Lim3 and eve to govern neuronal specification and differentiation. The roles of the product of exex include neuronal specification and differentiation.
- Evx2 [Search on AGR]
Homo sapiens This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. [provided by RefSeq, Sep 2009]