- rba-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable histone binding activity. Involved in cell fate specification; nematode male tail tip morphogenesis; and regulation of neurogenesis. Predicted to be located in nucleus. Predicted to be part of ESC/E(Z) complex and NuRD complex. Is an ortholog of human RBBP7 (RB binding protein 7, chromatin remodeling factor).
- lin-35 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cell cycle; negative regulation of vulval development; and positive regulation of brood size. Located in nucleus. Part of DRM complex and Rb-E2F complex. Expressed in several structures, including head and tail. Used to study intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including germ cell cancer (multiple); high grade glioma (multiple); and urinary system cancer (multiple). Is an ortholog of human RBL1 (RB transcriptional corepressor like 1) and RBL2 (RB transcriptional corepressor like 2).
- efl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including negative regulation of Ras protein signal transduction; negative regulation of vulval development; and regulation of gene expression. Part of DRM complex and Rb-E2F complex. Expressed in gonad. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate carcinoma. Is an ortholog of human E2F4 (E2F transcription factor 4).
- rbpl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Expressed in intestine; neurons; spermatheca; and vulva. Is an ortholog of human RBBP6 (RB binding protein 6, ubiquitin ligase).