paic-1

Caenorhabditis elegans

Enables identical protein binding activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase).

tdo-2

Caenorhabditis elegans

Predicted to enable heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in tryptophan catabolic process to acetyl-CoA. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Is an ortholog of human TDO2 (tryptophan 2,3-dioxygenase).

haao-1

Caenorhabditis elegans

Predicted to enable 3-hydroxyanthranilate 3,4-dioxygenase activity. Predicted to be involved in 'de novo' NAD biosynthetic process from tryptophan and quinolinate metabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human HAAO (3-hydroxyanthranilate 3,4-dioxygenase).

dhod-1

Caenorhabditis elegans

Predicted to enable dihydroorotate dehydrogenase activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleotide biosynthetic process. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Is an ortholog of human DHODH (dihydroorotate dehydrogenase (quinone)).

atic-1

Caenorhabditis elegans

Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Is an ortholog of human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase).

ctps-1

Caenorhabditis elegans

Predicted to enable ATP binding activity and CTP synthase activity. Predicted to be involved in 'de novo' CTP biosynthetic process and glutamine metabolic process. Expressed in germ line. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm; colorectal cancer; and immunodeficiency 24. Is an ortholog of human CTPS1 (CTP synthase 1) and CTPS2 (CTP synthase 2).

smc-3

Caenorhabditis elegans

Predicted to enable double-stranded DNA binding activity. Involved in establishment of mitotic sister chromatid cohesion. Located in chromatin and nucleus. Part of MIS12/MIND type complex and cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3; hepatocellular carcinoma; and intellectual disability. Is an ortholog of human SMC3 (structural maintenance of chromosomes 3).

T13G4.4

Caenorhabditis elegans

Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process.

adsl-1

Caenorhabditis elegans

Predicted to enable (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Predicted to be involved in 'de novo' AMP biosynthetic process. Predicted to be located in cytosol. Used to study adenylosuccinase lyase deficiency. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency; breast cancer; and prostate cancer. Is an ortholog of human ADSL (adenylosuccinate lyase).

gst-35

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).