clh-5

Caenorhabditis elegans

Predicted to enable voltage-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in endomembrane system and plasma membrane. Expressed in several structures, including head and tail. Human ortholog(s) of this gene implicated in Raynaud-Claes syndrome and X-linked recessive disease (multiple). Is an ortholog of human CLCN4 (chloride voltage-gated channel 4).

Clcn4

Rattus norvegicus

Predicted to enable antiporter activity and voltage-gated chloride channel activity. Predicted to be involved in chloride transport and non-motile cilium assembly. Predicted to be located in endoplasmic reticulum membrane; endosome; and lysosomal membrane. Predicted to be active in several cellular components, including Golgi apparatus; ciliary base; and cytoplasmic vesicle. Human ortholog(s) of this gene implicated in Raynaud-Claes syndrome. Orthologous to human CLCN4 (chloride voltage-gated channel 4); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Kdm5c

Rattus norvegicus

Predicted to enable several functions, including histone H3K4me/H3K4me2/H3K4me3 demethylase activity; identical protein binding activity; and zinc ion binding activity. Involved in response to toxic substance. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromatin and nucleus. Biomarker of schizophrenia. Human ortholog(s) of this gene implicated in descending colon cancer and syndromic X-linked intellectual disability Claes-Jensen type. Orthologous to human KDM5C (lysine demethylase 5C); PARTICIPATES IN histone modification pathway; renal cell carcinoma pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; bisphenol A.