Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and signal transduction. Located in nucleus. Expressed in several structures, including dorsal nerve cord; gonad; pharynx; and vulval precursor cell.
Enables small GTPase binding activity. Involved in several processes, including defense response to Gram-positive bacterium; intracellular signaling cassette; and vulval development. Predicted to be located in cytoplasm. Expressed in head neurons and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome with multiple lentigines (multiple); carcinoma (multiple); and central nervous system benign neoplasm (multiple). Is an ortholog of human BRAF (B-Raf proto-oncogene, serine/threonine kinase).
Predicted to enable clathrin binding activity. Involved in receptor-mediated endocytosis. Predicted to be located in intracellular membrane-bounded organelle and vesicle. Human ortholog(s) of this gene implicated in Parkinson's disease 19A. Is an ortholog of human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).