Predicted to enable 1-phosphatidylinositol-3-kinase activity and protein serine/threonine kinase activity. Involved in DNA damage checkpoint signaling; embryo development; and meiotic chromosome segregation. Located in nucleus. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Seckel syndrome 1; gastrointestinal system cancer (multiple); and pancreatic cancer. Is an ortholog of human ATR (ATR serine/threonine kinase).
Enables ubiquitin protein ligase activity. Involved in several processes, including DNA repair; nuclear chromosome segregation; and positive regulation of double-strand break repair via homologous recombination. Part of BRCA1-BARD1 complex. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Is an ortholog of human BRCA1 (BRCA1 DNA repair associated).
Enables uracil DNA N-glycosylase activity. Involved in base-excision repair. Located in nucleus. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Is an ortholog of human UNG (uracil DNA glycosylase).
Enables ubiquitin protein ligase activity. Involved in DNA repair; positive regulation of double-strand break repair via homologous recombination; and protein ubiquitination. Part of BRCA1-BARD1 complex. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Is an ortholog of human BARD1 (BRCA1 associated RING domain 1).
Enables DNA polymerase binding activity. Involved in positive regulation of DNA repair and positive regulation of DNA replication. Located in nucleus. Expressed in Z2 and Z3. Human ortholog(s) of this gene implicated in several diseases, including Lewy body dementia; ataxia-telangiectasia-like disorder-2; and kidney cancer (multiple). Is an ortholog of human PCNA (proliferating cell nuclear antigen).
Predicted to enable chromatin binding activity and damaged DNA binding activity. Involved in establishment of mitotic sister chromatid cohesion and meiotic cell cycle. Located in nucleus. Part of MIS12/MIND type complex and cohesin complex. Expressed in several structures, including SDQ; germ line; seam cell; touch receptor neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; carcinoma (multiple); and endometrial cancer. Is an ortholog of human RAD21 (RAD21 cohesin complex component) and RAD21L1 (RAD21 cohesin complex component like 1).
Predicted to enable clathrin binding activity. Involved in receptor-mediated endocytosis. Predicted to be located in intracellular membrane-bounded organelle and vesicle. Human ortholog(s) of this gene implicated in Parkinson's disease 19A. Is an ortholog of human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).