his-72

Caenorhabditis elegans

Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Located in nucleus. Part of nucleosome. Expressed in several structures, including germ cell; somatic cell; and in male. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 1 and Bryant-Li-Bhoj neurodevelopmental syndrome 2. Is an ortholog of human H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B).

his-71

Caenorhabditis elegans

Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be located in nucleus. Predicted to be part of nucleosome. Expressed in several structures, including somatic cell. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 1 and Bryant-Li-Bhoj neurodevelopmental syndrome 2. Is an ortholog of human H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B).

mboa-4

Caenorhabditis elegans

Predicted to enable acyltransferase activity. Predicted to be involved in lipid modification. Predicted to be located in membrane. Is an ortholog of human MBOAT1 (membrane bound glycerophospholipid O-acyltransferase 1) and MBOAT2 (membrane bound glycerophospholipid O-acyltransferase 2).

mboa-3

Caenorhabditis elegans

Predicted to enable acyltransferase activity. Predicted to be involved in lipid modification. Predicted to be located in membrane. Is an ortholog of human MBOAT1 (membrane bound glycerophospholipid O-acyltransferase 1) and MBOAT2 (membrane bound glycerophospholipid O-acyltransferase 2).

pssy-1

Caenorhabditis elegans

Predicted to enable L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Predicted to be involved in phosphatidylserine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Lenz-Majewski hyperostotic dwarfism. Is an ortholog of human PTDSS1 (phosphatidylserine synthase 1).

mboa-6

Caenorhabditis elegans

Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity and lysophospholipid acyltransferase activity. Involved in glycerophospholipid biosynthetic process; positive regulation of growth rate; and post-embryonic development. Predicted to be located in endoplasmic reticulum and membrane. Expressed in pharyngeal muscle cell and tail. Is an ortholog of human LPCAT3 (lysophosphatidylcholine acyltransferase 3).

ps

Drosophila melanogaster

pasilla (ps) encodes a nuclear RNA binding protein implicated in splicing. It is expressed at high levels in the embryonic salivary gland and other tissues. Loss of function results in a significant reduction in secretory volume and secretory vesicles in the salivary gland and irregular gland morphology.

H3f3b

Rattus norvegicus

Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II core promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. Predicted to be a structural constituent of chromatin. Involved in response to hormone. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 2. Orthologous to several human genes including H3-3B (H3.3 histone B); PARTICIPATES IN histone modification pathway; systemic lupus erythematosus pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-tert-Octylphenol.

Ulk2

Homo sapiens

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

H3f3a

Rattus norvegicus

Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II core promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in nucleosome assembly; oocyte maturation; and positive regulation of cell growth. Predicted to act upstream of or within several processes, including constitutive heterochromatin formation; negative regulation of chromosome condensation; and osteoblast differentiation. Predicted to be located in Barr body; chromosome, telomeric region; and nucleoplasm. Predicted to be part of inner kinetochore and nucleosome. Predicted to be active in chromatin and chromosome, centromeric region. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 1. Orthologous to several human genes including H3-3A (H3.3 histone A); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; fipronil.