- ufl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable UFM1 transferase activity. Predicted to be involved in negative regulation of NF-kappaB transcription factor activity; response to endoplasmic reticulum stress; and reticulophagy. Predicted to be located in endoplasmic reticulum membrane. Expressed in intestine. Is an ortholog of human UFL1 (UFM1 specific ligase 1).
- LRR [Search on AGR]
Drosophila melanogaster Leucine-rich repeat (LRR) encodes a protein that can negatively regulate NF-kappaB signaling.
- Nf-YC [Search on AGR]
Drosophila melanogaster Nuclear factor Y-box C (Nf-YC) encodes a transcription factor involved in axon guidance.
- Rtkn2 [Search on AGR]
Homo sapiens Involved in negative regulation of intrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of non-canonical NF-kappaB signal transduction. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
- Nf-YA [Search on AGR]
Drosophila melanogaster Nuclear factor Y-box A (Nf-YA) encodes a subunit of the nuclear transcription factor Y (NF-Y), also known as the CCAAT motif-binding factor (CBF). It is involved in eye and thorax development via gene expression regulation.
- Rela [Search on AGR]
Homo sapiens NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
- ENSRNOG00000065377 [Search on AGR]
Rattus norvegicus Predicted to enable GTP binding activity. Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction.
- Commd7 [Search on AGR]
Homo sapiens Enables NF-kappaB binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic vesicle and membrane. [provided by Alliance of Genome Resources, Apr 2025]
- Commd6 [Search on AGR]
Rattus norvegicus Predicted to enable NF-kappaB binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of NF-kappaB transcription factor activity. Orthologous to human COMMD6 (COMM domain containing 6); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
- Tonsl [Search on AGR]
Homo sapiens The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]