tag-275

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Is an ortholog of human ADAMDEC1 (ADAM like decysin 1).

F27D9.7

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Predicted to be located in membrane. Is an ortholog of human ADAMDEC1 (ADAM like decysin 1).

adm-2

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Predicted to be located in endosome membrane; lysosomal membrane; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); and lung disease (multiple). Is an ortholog of human ADAM19 (ADAM metallopeptidase domain 19) and ADAM33 (ADAM metallopeptidase domain 33).

DOCK6-AS1

Homo sapiens

ASSOCIATED WITH Adams-Oliver syndrome; Adams-Oliver Syndrome 1; Adams-Oliver Syndrome 2

adm-4

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Involved in Notch signaling pathway and cell fate specification. Predicted to be located in plasma membrane. Expressed in gonad; hypodermis; tail; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; renal fibrosis; and type 2 diabetes mellitus. Is an ortholog of human ADAM17 (ADAM metallopeptidase domain 17).

TMUE_2000010475

Trichuris muris

Is predicted to encode a protein with the following domains: ADAM, cysteine-rich domain and ADAM cysteine-rich.

unc-71

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Located in membrane. Expressed in several structures, including buccal cavity; excretory system; nerve ring; neuronal sheath cell; and neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Is an ortholog of human ADAM22 (ADAM metallopeptidase domain 22) and ADAM23 (ADAM metallopeptidase domain 23).

rrc-1

Caenorhabditis elegans

Enables GTPase activator activity. Involved in positive regulation of GTPase activity. Expressed in GLRL; GLRR; coelomocyte; excretory cell; and uterine seam cell. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and coronary artery disease. Is an ortholog of human ARHGAP33 (Rho GTPase activating protein 33).

H12D21.10

Caenorhabditis elegans

Predicted to enable protein O-acetylglucosaminyltransferase activity. Predicted to be involved in protein O-GlcNAcylation via threonine. Predicted to be located in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Is an ortholog of human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase).

F46H5.4

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; developmental and epileptic encephalopathy 23; and gastrointestinal system cancer (multiple). Is an ortholog of human DOCK8 (dedicator of cytokinesis 8).