Enables MAP kinase kinase kinase activity. Involved in stress-activated MAPK cascade. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Is an ortholog of human MAP3K20 (mitogen-activated protein kinase kinase kinase 20).
Is affected by bet-1 and mys-1 based on RNA-seq studies. Is predicted to encode a protein with the following domains: Zygotic Embryogenesis-Associated Protein; F-box domain; F-box associated domain, type 2; and F-box associated.
Is affected by ogt-1; eri-1; and rde-3 based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Zygotic Embryogenesis-Associated Protein; F-box domain; F-box associated domain, type 2; and F-box associated.