eng-1

Caenorhabditis elegans

Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to be located in cytosol. Expressed in pharyngeal cell. Is an ortholog of human ENGASE (endo-beta-N-acetylglucosaminidase).

ergo-1

Caenorhabditis elegans

Enables DEAD/H-box RNA helicase binding activity and siRNA binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing and siRNA processing. Located in cytoplasm. Expressed in several structures, including gonad; neurons; pharynx; seam cell; and vulva.

chhy-1

Caenorhabditis elegans

Enables hexosaminidase activity. Involved in chondroitin sulfate catabolic process. Expressed in PLML; PLMR; head; intestinal cell; and vulva. Human ortholog(s) of this gene implicated in mucopolysaccharidosis IX. Is an ortholog of human HYAL2 (hyaluronidase 2).

apn-1

Caenorhabditis elegans

Enables 3'-tyrosyl-DNA phosphodiesterase activity; DNA-(apurinic or apyrimidinic site) endonuclease activity; and double-stranded DNA 3'-5' DNA exonuclease activity. Involved in base-excision repair. Located in nucleus. Expressed in hermaphrodite gonad and male gonad.

rab-35

Caenorhabditis elegans

Enables GTPase activating protein binding activity and ankyrin repeat binding activity. Involved in endocytic recycling. Located in early endosome; plasma membrane; and recycling endosome membrane. Expressed in several structures, including oocyte. Is an ortholog of human RAB35 (RAB35, member RAS oncogene family).

rrp-8

Caenorhabditis elegans

Predicted to enable methylated histone binding activity. Predicted to be involved in cellular response to glucose starvation; rDNA heterochromatin formation; and regulation of transcription by glucose. Predicted to be located in nucleolus. Predicted to be part of chromatin silencing complex and rDNA heterochromatin. Expressed widely. Is an ortholog of human RRP8 (ribosomal RNA processing 8).

rab-39

Caenorhabditis elegans

Enables GTP binding activity. Involved in positive regulation of response to oxidative stress. Predicted to be located in Golgi apparatus; cytoplasmic vesicle membrane; and plasma membrane. Expressed in head mesodermal cell; head neurons; hypodermis; rectal gland cell; and tail neurons. Human ortholog(s) of this gene implicated in Waisman syndrome and non-syndromic X-linked intellectual disability 72. Is an ortholog of human RAB39A (RAB39A, member RAS oncogene family) and RAB39B (RAB39B, member RAS oncogene family).

apy-1

Caenorhabditis elegans

Enables GDP phosphatase activity and UDP phosphatase activity. Involved in several processes, including determination of adult lifespan; endoplasmic reticulum unfolded protein response; and ribonucleoside diphosphate catabolic process. Located in membrane. Expressed in hypodermis and pharynx. Human ortholog(s) of this gene implicated in Desbuquois dysplasia and multiple epiphyseal dysplasia 7. Is an ortholog of human CANT1 (calcium activated nucleotidase 1).

riok-1

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including gamete generation; positive regulation of vulval development; and regulation of intracellular signal transduction. Predicted to be located in cytosol. Predicted to be part of preribosome, small subunit precursor. Expressed in gonad; nervous system; and vulva. Is an ortholog of human RIOK1 (RIO kinase 1).

cup-5

Caenorhabditis elegans

Predicted to enable NAADP-sensitive calcium-release channel activity and phosphatidylinositol-3,5-bisphosphate binding activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; determination of adult lifespan; and lysosomal lumen acidification. Located in endolysosome and lysosomal membrane. Expressed in coelomocyte; head; intestinal cell; and neurons. Used to study mucolipidosis type IV. Human ortholog(s) of this gene implicated in glycoproteinosis and mucolipidosis type IV. Is an ortholog of human MCOLN1 (mucolipin TRP cation channel 1); MCOLN2 (mucolipin TRP cation channel 2); and MCOLN3 (mucolipin TRP cation channel 3).