RP3439

C elegans

OD2435

C elegans

RM1743

Caenorhabditis elegans

OD2283

Caenorhabditis elegans

RM777

Caenorhabditis elegans

unc-26

Caenorhabditis elegans

Predicted to enable inositol-1,4,5-trisphosphate 5-phosphatase activity; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in several processes, including nitrogen compound transport; regulation of locomotion; and synaptic vesicle endocytosis. Located in synapse. Expressed in tail and ventral cord neurons. Used to study Down syndrome and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease 20 and developmental and epileptic encephalopathy 53. Is an ortholog of human SYNJ1 (synaptojanin 1).