gene: sorf-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatidylinositol 3-kinase inhibitor activity. Involved in endosomal transport; organelle fusion; and positive regulation of early endosome to late endosome transport. Located in early endosome lumen and late endosome lumen. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 and hydrocephalus. Is an ortholog of human WDR81 (WD repeat domain 81).
gene: sel-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein kinase binding activity. Involved in several processes, including apical protein localization; negative regulation of Notch signaling pathway; and regulation of vulval development. Located in perinuclear region of cytoplasm. Expressed in several structures, including ganglia; pharyngeal-intestinal valve; rectum; somatic nervous system; and vulva. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in common variable immunodeficiency 8 and stomach cancer. Is an ortholog of human LRBA (LPS responsive beige-like anchor protein) and NBEA (neurobeachin).